Smart CPAP Algorithms 2026: AutoSet, AutoCPAP, EPR, and SmartFlex Explained
By Dr. Sarah Mitchell, Certified Respiratory Therapist · Published 2026-06-03 · 8 min read
Modern CPAPs use real-time machine learning to titrate pressure breath-by-breath. Here is how each manufacturer's algorithm works.
CPAP Algorithms in 2026
ResMed AutoSet (AirSense 11)
- Detects flow limitation, snore, apnea/hypopnea
- Adjusts pressure every 2 minutes
- EPR (Expiratory Pressure Relief) lowers pressure on exhale
Philips SmartFlex (DreamStation 2)
- Bi-Flex on exhale + AutoTrial mode
- New cellular ML titration uses cloud population data
React Health Luna G3
- Auto-bilevel mode
- AutoEPAP for central apnea recognition
How to Choose
- Pure obstructive apnea: any AutoSet-class machine
- Mixed apnea or treatment-emergent central: BiPAP ASV — see BiPAP machines
- Travel: smaller AirMini or DreamStation Go
Mask Matters More Than Algorithm
Adherence drops 35% with the wrong mask. Browse our fit-guaranteed CPAP mask collection.
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